Pseudomonas aeruginosa PA14 wild-type vs the tpbA (PA14_13660) mutant
Ontology highlight
ABSTRACT:
ORGANISM(S): Pseudomonas aeruginosa
SUBMITTER: Akihiro Ueda
PROVIDER: E-GEOD-13871 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).
Ueda Akihiro A Wood Thomas K TK
PLoS pathogens 20090619 6
With the opportunistic pathogen Pseudomonas aeruginosa, quorum sensing based on homoserine lactones was found to influence biofilm formation. Here we discern a mechanism by which quorum sensing controls biofilm formation by screening 5850 transposon mutants of P. aeruginosa PA14 for altered biofilm formation. This screen identified the PA3885 mutant, which had 147-fold more biofilm than the wild-type strain. Loss of PA3885 decreased swimming, abolished swarming, and increased attachment, althoug ...[more]
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