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Profiling the target genes for ZIP repressor in MCF-7

ABSTRACT: Using ChIP-DSL technology from Aviva Systems Biology to find out the whole genome targets for ZIP transcription repressor We analyzed arrays using specific ZIP antibody and negative control to acquire the enriched ratio of each gene

ORGANISM(S): Homo sapiens

SUBMITTER: Yongfeng Shang

PROVIDER: E-GEOD-13905 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis.

Li Ruifang R Zhang Hua H Yu Wenhua W Chen Yupeng Y Gui Bin B Liang Jing J Wang Yan Y Sun Luyang L Yang Xiaohan X Zhang Yu Y Shi Lei L Li Yanyan Y Shang Yongfeng Y

The EMBO journal 20090730 18

Despite the importance of epidermal growth factor receptor (EGFR) in animal development and malignant transformation, surprisingly little is known about the regulation of its expression. Here, we report a novel zinc finger and G-patch domain-containing protein, ZIP. We demonstrated that ZIP acts as a transcription repressor through the recruitment of the nucleosome remodelling and deacetylase complex. Transcriptional target analysis revealed that ZIP regulates several cellular signalling pathway ...[more]

PMID: 19644445

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