Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yongfeng Shang
PROVIDER: E-GEOD-14260 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Yan Y Zhang Hua H Chen Yupeng Y Sun Yimin Y Yang Fen F Yu Wenhua W Liang Jing J Sun Luyang L Yang Xiaohan X Shi Lei L Li Ruifang R Li Yanyan Y Zhang Yu Y Li Qian Q Yi Xia X Shang Yongfeng Y
Cell 20090801 4
Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report that LSD1 is an integral component of the Mi-2/nucleosome remodeling and deacetylase (NuRD) complex. Transcriptional target analysis revealed that the LSD1/NuRD complexes regulate several cellular signaling pathways including TGFbeta1 signaling pathway that are critically involved in cell proliferation, survival, and epithelial-to-mesenchym ...[more]