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Transcription profiling of mouse spermatogonia in wild type vs Zpf145 knockout backgrounds reveals Plzf is essential for maintenance of spermatogonial stem cells.

ABSTRACT: Expression analysis of spermatogonia in a wild type or Zfp145 knock out background

ORGANISM(S): Mus musculus

SUBMITTER: Agnes Viale

PROVIDER: E-GEOD-1399 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Essential role of Plzf in maintenance of spermatogonial stem cells.

Costoya José A JA Hobbs Robin M RM Barna Maria M Cattoretti Giorgio G Manova Katia K Sukhwani Meena M Orwig Kyle E KE Wolgemuth Debra J DJ Pandolfi Pier Paolo PP

Nature genetics 20040523 6

Little is known of the molecular mechanisms whereby spermatogonia, mitotic germ cells of the testis, self-renew and differentiate into sperm. Here we show that Zfp145, encoding the transcriptional repressor Plzf, has a crucial role in spermatogenesis. Zfp145 expression was restricted to gonocytes and undifferentiated spermatogonia and was absent in tubules of W/W(v) mutants that lack these cells. Mice lacking Zfp145 underwent a progressive loss of spermatogonia with age, associated with increase ...[more]

PMID: 15156143

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