Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Susan Logan
PROVIDER: E-GEOD-14043 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nwachukwu Jerome C JC Mita Paolo P Ruoff Rachel R Ha Susan S Wang Qianben Q Huang S Joseph SJ Taneja Samir S SS Brown Myles M Gerald William L WL Garabedian Michael J MJ Logan Susan K SK
Cancer research 20090324 7
The androgen receptor (AR) directs diverse biological processes through interaction with coregulators such as AR trapped clone-27 (ART-27). Our results show that ART-27 is recruited to AR-binding sites by chromatin immunoprecipitation analysis. In addition, the effect of ART-27 on genome-wide transcription was examined. The studies indicate that loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression. Surprisingly, classes of genes tha ...[more]