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Genome-wide impact of ART-27 loss on androgen-regulated transcription in prostate cancer cells

ABSTRACT: The androgen receptor (AR) directs diverse biological processes through interaction with coregulators such as androgen receptor trapped clone-27 (ART-27). The impact of ART-27 on genome-wide transcription was examined. The studies indicate that loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression. Surprisingly, classes of genes that are upregulated upon ART-27 depletion include regulators of DNA damage checkpoint and cell cycle progression, suggesting that ART-27 functions to keep expression levels of these genes low. Keywords: LNCaP, cell type comparison, UXT, ART-27, androgen receptor, R1881, AR, androgen-regulated gene expression, prostate cancer

ORGANISM(S): Homo sapiens

PROVIDER: GSE14043 | GEO | 2009/05/28

SECONDARY ACCESSION(S): PRJNA112401

REPOSITORIES: GEO

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