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Lymph nodes with follicular lymphoma or reactive hyperplasia

ABSTRACT: Comparison of gene expression profiles of follicular lymphoma vs. reactive lymph nodes. 8 cases of follicular lymphoma; 5 cases of reactive lymph nodes.

ORGANISM(S): Homo sapiens

SUBMITTER: Jack Zhu

PROVIDER: E-GEOD-14214 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome.

Killian J Keith JK Bilke Sven S Davis Sean S Walker Robert L RL Killian M Scott MS Jaeger Erich B EB Chen Yidong Y Hipp Jason J Pittaluga Stefania S Raffeld Mark M Cornelison Robert R Smith William I WI Bibikova Marina M Fan Jian-Bing JB Emmert-Buck Michael R MR Jaffe Elaine S ES Meltzer Paul S PS

Cancer research 20090120 3

Emerging technologies allow broad profiling of the cancer genome for differential DNA methylation relative to benign cells. Herein, bisulfite-modified DNA from lymph nodes with either reactive hyperplasia or follicular lymphoma (FL) were analyzed using a commercial C/UpG genotyping assay. Two hundred fifty-nine differentially methylated targets (DMT) distributed among 183 unique genes were identified in FL. Comparison of matched formalin-fixed, paraffin-embedded and frozen surgical pathology rep ...[more]

PMID: 19155300

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Lymph nodes with follicular lymphoma or reactive hyperplasia

Project description:Comparison of gene expression profiles of follicular lymphoma vs. reactive lymph nodes.

2011-09-27 | GSE14214 | GEO

Transcription Profiles of Regulatory T Cells in Follicular Lymphoma Lymph Nodes, Normal Lymph Nodes and Reactive Lymph Nodes

Project description:We have previously shown that Tregs infiltrating follicular lymphoma lymph nodes (FLN) are quantitatively and qualitatively different than those infiltrating normal and reactive nodes (NLN, RLN, respectively). To gain insight into how such Treg populations differ, we performed RNA sequence (RNAseq) analyses on flow sorted Tregs from all three sources. We identify several molecules that could contribute to the observed increased suppressive capacity of FLN tregs, including upregulation of CTLA-4, IL-10, and GITR, all confirmed by protein expression. In addition, we identify, and confirm functionally, a novel mechanism by which Tregs target to and accumulate within a human tumor microenvironment, through the down regulation of S1PR1, SELL (L-selectin) and CCR7, potentially resulting in greater lymph node retention. In addition we identify and confirm functionally the upregulation of CXCR5, CXCL13 and IL-16 demonstrating the unique ability of the follicular derived Tregs to localize and accumulate within not only the malignant lymph node, but also localize and accumulate within the malignant B cell follicle itself. Such findings offer significant new insights into how FLN Tregs may contribute to the biology of follicular lymphoma and identify several novel therapeutic targets.

2016-05-26 | GSE74102 | GEO

Expression data from human lymphoma endothelium and reactive lymph node-derived endothelium

Project description:Angiogenesis plays a key role in tumor metastasis. Many genes may act in this process including formation of vessels, immune evasion,etc. Different gene expression profiles between lymphoma endothelium cells and reactive lymph node-derived endothelium cells may uncover these genes. And intensive mechanism researches on such key genes may explain the mechanisim of tumor-specific angiogenesis and help to explore effective treatment strategies to prevent/reverse tumor metastasis. We use microarrays to detail gene expression profiles of human lymphoma endothelium and reactive lymph node-derived endothelium. Lymph nodes were taken from surgery samples of cases pathologically diagnosed DLBCL (diffuse large B-cell lymphoma), PTL (peripheral T cell lymphoma) and reactive lymph nodes. The pure endothelium cells were isolated by LCM after immunohistochemical staining of CD34. We found Tim-3 was preferentially expressed on lymphoma-derived ECs via different expression profiles between lymphoma ECs and reactive lymph node-derived ECs. Intensive researches were carried out on Tim-3-expressing -ECs and we found that Tim-3 -expressing-Ecs may play important role on EC-mediated tumor evasion.

2010-01-14 | E-GEOD-19882 | biostudies-arrayexpress

Gene expression profiling of human peripheral T cell lymphoma cases vs. reactive lymph nodes

Project description:Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. However, little is known about the molecular pathogenesis of this disease. In this study, we performed a gene expression profiling analysis of a series of 38 PTCL cases in order to find deregulated pathways or genes that could become therapeutic agents for PTCL patients. 38 PTCL cases and 6 reactive lymph nodes were hybridized with the Universal Human Reference RNA (Stratagene, La Jolla, CA), which served as the reference sample.

2012-07-31 | E-GEOD-36172 | biostudies-arrayexpress

cDNA microarray assay of lymph node biopsies diagnosed as lymphoma or as reactive tissue

Project description:Gene expression profiling of biopsied human lymph node (LN) tissue comparing each patient sample against mobilised peripheral blood stem cells (PBSC), the reference channel Evaluate whether gene expression microarray can diagnose lymph node biopsies as reactive or as one of three main types of lymphoma: classical Hodgkin’s lymphoma (cHL), diffuse large B cell lymphoma (DLBCL) or follicular lymphoma (FL). Two condition experiment, LN vs mobilised PBSC, 116 cases assayed, 1 replicate per array

2012-11-28 | E-GEOD-23647 | biostudies-arrayexpress

Homo sapiens

Project description:Lymph nodes with follicular lymphoma or reactive hyperplasia

| PRJNA111339 | ENA

cDNA microarray assay of lymph node biopsies diagnosed as lymphoma or as reactive tissue

2012-11-28 | GSE23647 | GEO

Expression data of human stromal cells isolated from Follicular lymphoma (FL) or non-malignant reactive (RLN) lymph nodes

Project description:Expression data of human stromal cells isolated from Follicular lymphoma (FL) or non-malignant reactive (RLN) lymph nodes

| PRJNA638181 | ENA

Homo sapiens

Project description:Transcription Profiles of Regulatory T Cells in Follicular Lymphoma Lymph Nodes, Normal Lymph Nodes and Reactive Lymph Nodes

| PRJNA299009 | ENA

MicroRNA expression profile of non-Hodgkin B-cell lymphomas, reactive lymph nodes, pure B and T cell, lymphoblastoid cell lines and mononucleosis

Project description:MicroRNAs expression profile was acquired in 99 frozen tissues corresponding to 14 Burkitt's lymphoma, 17 diffuse large B-cell lymphoma, 29 follicular lymphoma, 19 mantle cell lymphoma, 8 primary mediastinal B-cell lymphoma and 12 lymph nodes. Additionally, we performed microRNA expression profile of 14 Burkitts' lymphoma cell lines, 2 mantle cell lymphoma cell lines, 5 acute lymphoblastic leukemia cell preparations, 5 samples of mononucleosis cells, 4 Epstein Barr virus infected lymphoblastoid cell lines (EBV), 27 purified samples of B cells at different stage of development (13 GC-CD23-/CD39-, 11 GC-CD5- and 3 GC-CD5+), 4 peripheral blood CD19+ B cells, 4 purified samples of T cells (2 CD4+ and 2 CD8+) and 2 samples of bone marrow CD34+ cells. The data were used to discriminate among diverse pathological and nonpathological samples and to identify microRNAs expression differences between pathological samples and their nonpathological counterparts.

2017-08-20 | E-MTAB-6035 | biostudies-arrayexpress

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