Unknown,Transcriptomics,Genomics,Proteomics

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CDNA microarray assay of lymph node biopsies diagnosed as lymphoma or as reactive tissue

ABSTRACT: Gene expression profiling of biopsied human lymph node (LN) tissue comparing each patient sample against mobilised peripheral blood stem cells (PBSC), the reference channel Evaluate whether gene expression microarray can diagnose lymph node biopsies as reactive or as one of three main types of lymphoma: classical Hodgkin’s lymphoma (cHL), diffuse large B cell lymphoma (DLBCL) or follicular lymphoma (FL). Two condition experiment, LN vs mobilised PBSC, 116 cases assayed, 1 replicate per array

ORGANISM(S): Homo sapiens

SUBMITTER: David Ma 

PROVIDER: E-GEOD-23647 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Discriminating lymphomas and reactive lymphadenopathy in lymph node biopsies by gene expression profiling.

Loi To Ha TH   Campain Anna A   Bryant Adam A   Molloy Tim J TJ   Lutherborrow Mark M   Turner Jennifer J   Yang Yee Hwa Jean YH   Ma David D F DD  

BMC medical genomics 20110331

<h4>Background</h4>Diagnostic accuracy of lymphoma, a heterogeneous cancer, is essential for patient management. Several ancillary tests including immunophenotyping, and sometimes cytogenetics and PCR are required to aid histological diagnosis. In this proof of principle study, gene expression microarray was evaluated as a single platform test in the differential diagnosis of common lymphoma subtypes and reactive lymphadenopathy (RL) in lymph node biopsies.<h4>Methods</h4>116 lymph node biopsies  ...[more]

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