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Transcription profiling of branching and non-branching regions of the mouse embryonic lung.

ABSTRACT: During development, the proximal and distal regions of respiratory tract undergo distinct processes that ultimately give rise to conducting airways and alveoli. To gain insights into the genetic pathways differentially activated in these regions when branching morphogenesis is initiating, we characterized their transcriptional profiles in murine rudiments isolated at embryonic day 11.5.

ORGANISM(S): Mus musculus

SUBMITTER: Jining Lu

PROVIDER: E-GEOD-1423 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung.

Lü Jining J Qian Jun J Izvolsky Konstantin I KI Cardoso Wellington V WV

Developmental biology 20040901 2

During development, the proximal and distal regions of respiratory tract undergo distinct processes that ultimately give rise to conducting airways and alveoli. To gain insights into the genetic pathways differentially activated in these regions when branching morphogenesis is initiating, we characterized their transcriptional profiles in murine rudiments isolated at embryonic (E) day 11.5. By using oligonucleotide microarrays, we identified 83 and 128 genes preferentially expressed in branching ...[more]

PMID: 15328023

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Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung

Project description:During development, the proximal and distal regions of respiratory tract undergo distinct processes that ultimately give rise to conducting airways and alveoli. To gain insights into the genetic pathways differentially activated in these regions when branching morphogenesis is initiating, we characterized their transcriptional profiles in murine rudiments isolated at embryonic day 11.5. Keywords: parallel sample

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