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Transcription profiling of vastus lateralis muscle biopsies from young and old male human subjects

ABSTRACT: This series includes the global gene expression profile of the vastus lateralis muscle for 10 young (19-25 years old) and 12 older (70-80 years old) male subjects.

ORGANISM(S): Homo sapiens

SUBMITTER: Susan Kandarian

PROVIDER: E-GEOD-1428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of a molecular signature of sarcopenia.

Giresi Paul G PG Stevenson Eric J EJ Theilhaber Joachim J Koncarevic Alan A Parkington Jascha J Fielding Roger A RA Kandarian Susan C SC

Physiological genomics 20050201 2

Investigating the molecular mechanisms underlying sarcopenia in humans with the use of microarrays has been complicated by low sample size and the variability inherent in human gene expression profiles. We have conducted a study using Affymetrix GeneChips to identify a molecular signature of aged skeletal muscle. The molecular signature was defined as the set of expressed genes that best distinguished the vastus lateralis muscle of young (n = 10) and older (n = 12) male subjects, when a k-neares ...[more]

PMID: 15687482

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