Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joshua Mendell
PROVIDER: E-GEOD-14302 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chang Tsung-Cheng TC Zeitels Lauren R LR Hwang Hun-Way HW Chivukula Raghu R RR Wentzel Erik A EA Dews Michael M Jung Jason J Gao Ping P Dang Chi V CV Beer Michael A MA Thomas-Tikhonenko Andrei A Mendell Joshua T JT
Proceedings of the National Academy of Sciences of the United States of America 20090211 9
Direct control of microRNA (miRNA) expression by oncogenic and tumor suppressor networks results in frequent dysregulation of miRNAs in cancer cells and contributes to tumorigenesis. We previously demonstrated that activation of the c-Myc oncogenic transcription factor (Myc) broadly influences miRNA expression and in particular leads to widespread miRNA down-regulation. miRNA transcripts repressed by Myc include several with potent tumor suppressor activity such as miR-15a/16-1, miR-34a, and let ...[more]