Testicular gene expression profiles in infertile patients with AZFc deletions of the Y chromosome
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Carlo Foresta
PROVIDER: E-GEOD-14310 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Testis transcriptome analysis in male infertility: new insight on the pathogenesis of oligo-azoospermia in cases with and without AZFc microdeletion.
Gatta Valentina V Raicu Florina F Ferlin Alberto A Antonucci Ivana I Scioletti Anna Paola AP Garolla Andrea A Palka Giandomenico G Foresta Carlo C Stuppia Liborio L
BMC genomics 20100624
<h4>Background</h4>About 10% of cases of male infertility are due to the presence of microdeletions within the long arm of the Y chromosome (Yq). Despite the large literature covering this critical issue, very little is known about the pathogenic mechanism leading to spermatogenesis disruption in patients carrying these microdeletions. In order to identify the presence of specific molecular pathways leading to spermatogenic damage, testicular gene expression profiling was carried out by employin ...[more]
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