Dataset Information
Transcription profiling of mouse F9 embryonal carcinoma cells exposed to differentiating agents (retinoic acid or trichostatin A) vs controls
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Niquiche Sangster
PROVIDER: E-GEOD-1437 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment.
Cancer biology & therapy 20041124 11
Regulation of tissue homeostasis is crucial to disease prevention; cell division, cell cycle arrest, differentiation and apoptosis have to be tightly controlled in order to maintain this homeostasis. Retinoic acid (RA) and the histone deacetylase inhibitors (HDACIs) have profound effects on these processes and thus may be critical regulators of homeostasis. Consequently, RA and/or histone deacetylase inhibitors are currently being tested in clinical trials for a variety of cancers. Unfortunately ...[more]
