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Gene expression studies in normal, dysplastic and malignant cervical tissues

ABSTRACT: Gene expression profiling of normal cervix, CIN's and cancer cervix, with an intent to identify genes involved in the malignant transformation of normal cervix and to identify genes which can be used as biomarkers for early diagnosis. Identification of genes for predicting radiation response using microarray gene expression studies Keywords: Patient tissue samples Two dye experiments using Universal control RNA (Stratagene) and RNA from tissues. Biological replicates: Normal = 5; CIN1=4; CIN3=3; Cervical cancers = 28. One replicate per array.

ORGANISM(S): Homo sapiens

SUBMITTER: T Rajkumar

PROVIDER: E-GEOD-14404 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A 7 gene expression score predicts for radiation response in cancer cervix.

Rajkumar Thangarajan T Vijayalakshmi Neelakantan N Sabitha Kesavan K Shirley Sundersingh S Selvaluxmy Ganesharaja G Bose Mayil Vahanan MV Nambaru Lavanya L

BMC cancer 20091015

<h4>Background</h4>Cervical cancer is the most common cancer among Indian women. The current recommendations are to treat the stage IIB, IIIA, IIIB and IVA with radical radiotherapy and weekly cisplatin based chemotherapy. However, Radiotherapy alone can help cure more than 60% of stage IIB and up to 40% of stage IIIB patients.<h4>Methods</h4>Archival RNA samples from 15 patients who had achieved complete remission and stayed disease free for more than 36 months (No Evidence of Disease or NED gr ...[more]

PMID: 19832977

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