Loss of the actin remodeler Eps8 causes calorie restriction and improved metabolic status in mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Marion Horsch
PROVIDER: E-GEOD-14454 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice.
Tocchetti Arianna A Soppo Charlotte Blanche Ekalle CB Zani Fabio F Bianchi Fabrizio F Gagliani Maria Cristina MC Pozzi Benedetta B Rozman Jan J Elvert Ralf R Ehrhardt Nicole N Rathkolb Birgit B Moerth Corinna C Horsch Marion M Fuchs Helmut H Gailus-Durner Valérie V Beckers Johannes J Klingenspor Martin M Wolf Eckhard E Hrabé de Angelis Martin M Scanziani Eugenio E Tacchetti Carlo C Scita Giorgio G Di Fiore Pier Paolo PP Offenhäuser Nina N
PloS one 20100302 3
<h4>Background</h4>In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan.<h4>Methodology/principal findings</h4>Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced body weight, partial resistance to age- or diet-induced obesity, and overall improved metabolic status. Alteration in the liver gene expression profile, in behav ...[more]
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