Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Murine hepatocellular carcinoma of AlbLTa/b transgenic mice and age matched C57BL/6 mice - 18 months old.

ABSTRACT: aCGH analysis of murine transgenic liver tissues affected with HCC, hybridized with age (18 months) and sex matched C57BL/6 mice. Moreover, 18months old C57BL/6 livers were hybridized with independent 18 months old C57BL/6 livers for control. Keywords: Array comparative genomic hybridization analysis (aCGH). Independent HCC of AlbLTab mice were hybridized with independent C57BL/6 mice.

ORGANISM(S): Mus musculus

SUBMITTER: M Heikenwälder 

PROVIDER: E-GEOD-14467 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Hepatitis B and C viruses (HBV and HCV) cause chronic hepatitis and hepatocellular carcinoma (HCC) by poorly understood mechanisms. We show that cytokines lymphotoxin (LT) alpha and beta and their receptor (LTbetaR) are upregulated in HBV- or HCV-induced hepatitis and HCC. Liver-specific LTalphabeta expression in mice induces liver inflammation and HCC, causally linking hepatic LT overexpression to hepatitis and HCC. Development of HCC, composed in part of A6(+) oval cells, depends on lymphocyte  ...[more]

Similar Datasets

Transcriptomics Murine hepatocellular carcinoma of MCL1-/- transgenic mice and age matched alb cre mice - 12 months old.
2010-05-16 | E-GEOD-16580 | biostudies-arrayexpress
Genomics Murine hepatocellular carcinoma of AlbLTa/b transgenic mice and age matched C57BL/6 mice - 18 months old.
2009-07-29 | GSE14467 | GEO
Genomics Murine hepatocellular carcinoma of MCL1-/- transgenic mice and age matched alb cre mice - 12 months old.
2009-12-31 | GSE16580 | GEO
Transcriptomics Single cell RNA-seq mapping of chronological obesity-HCC progression in C57BL/6 mice fed a CD-HFD
2024-02-17 | GSE232182 | GEO
Transcriptomics Single cell RNA-seq of single cell suspension from the HCC region of mice fed CD-HFD for 15 mice and treated with FABP5 inhibitor or control
2024-02-17 | GSE231818 | GEO
Transcriptomics Identification of HCC-specific genes in a rat model of hepatocarcinogenesis
2023-05-23 | E-MTAB-11977 | biostudies-arrayexpress
Genomics E-GEOD-37468
2015-07-08 | E-GEOD-37468 | ExpressionAtlas
Genomics E-GEOD-37559
2015-07-08 | E-GEOD-37559 | ExpressionAtlas
Proteomics Gut microbial functional maturation and succession during early life
2018-07-16 | PXD009056 | Pride
Transcriptomics Ectopic lymphoid structures as microniches for tumor progenitor cells
2015-09-25 | E-MTAB-3848 | biostudies-arrayexpress