Transcription profiling of mouse LE-AP-2a mutants vs. wild-type P0 littermate lenses to investigate cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jiri Zavadil
PROVIDER: E-GEOD-14536 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.
Pontoriero Giuseppe F GF Deschamps Paula P Ashery-Padan Ruth R Wong Ryan R Yang Ying Y Zavadil Jiri J Cvekl Ales A Sullivan Shelley S Williams Trevor T West-Mays Judith A JA
Developmental dynamics : an official publication of the American Association of Anatomists 20080301 3
In this study, we have created a conditional deletion of AP-2alpha in the developing mouse lens (Le-AP-2alpha mutants) to determine the cell-autonomous requirement(s) for AP-2alpha in lens development. Embryonic and adult Le-AP-2alpha mutants exhibited defects confined to lens placode derivatives, including a persistent adhesion of the lens to the overlying corneal epithelium (or lens stalk). Expression of known regulators of lens vesicle separation, including Pax6, Pitx3, and Foxe3 was observed ...[more]
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