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Bifidobacterium longum mutants and resistance to Heat-Shock

ABSTRACT: Transcriptional profiling of Bifidobacterium longum mutants versus wt strain in exponentional phase, with or without heat-shock treatment, and in stationary phase Keywords: Characterization of natural mutants Two B. longum mutants (NCC2912 and NCC2913) were analysed versus the wt strain NCC2705 in three conditions : exponential phase 37Â°, exponential phase with 7 min 50Â° heat shock, stationary phase. Two biologic replicates and 2 technical replicates

ORGANISM(S): Bifidobacterium longum

SUBMITTER: Bernard Berger

PROVIDER: E-GEOD-14628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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HspR mutations are naturally selected in Bifidobacterium longum when successive heat shock treatments are applied.

Berger B B Moine D D Mansourian R R Arigoni F F

Journal of bacteriology 20100101 1

The development of molecular tools allowed light to be shed on several widespread genetic mechanisms aiming at limiting the effect of molecular damage on bacterial survival. For some bacterial taxa, there are limited tools in the genetic toolbox, which restricts the possibilities to investigate the molecular basis of their stress response. In that case, an alternative strategy is to study genetic variants of a strain under stress conditions. The comparative study of the genetic determinants resp ...[more]

PMID: 19880603

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