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Transcription profiling of Drosophila Spargel mutants vs. controls to investigate the effect of Spargel on transcriptional changes mediated by the insulin-signalling pathway

ABSTRACT: Insulin signalling activity is well known to mediate transcriptional changes in response to nutrients and it is changed in the spargel mutant. We performed a genome-wide microarray study to investigate the role of Spargel as a transcriptional coregulator downstream of insulin receptor signalling. Experiment Overall Design: To investigate the effect of Spargel on transcriptional changes mediated by the insulin-signalling pathway we analyzed 12 samples in total: three biological replicates of the control with or without UAS-Inr (Inr_wt and ctrl_wt) and three biological replicates of the spargel mutant with or without UAS-Inr (Inr_KGand ctrl_KG).

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Stefanie Tiefenboeck

PROVIDER: E-GEOD-14779 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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