Altered modulation of WNT-β-catenin and PI3K/Akt pathways in IgA nephropathy
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Grazia Serino
PROVIDER: E-GEOD-14795 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Altered modulation of WNT-beta-catenin and PI3K/Akt pathways in IgA nephropathy.
Cox Sharon N SN Sallustio Fabio F Serino Grazia G Pontrelli Paola P Verrienti Raffaella R Pesce Francesco F Torres Diletta D DD Ancona Nicola N Stifanelli Patrizia P Zaza Gianluigi G Schena Francesco P FP
Kidney international 20100519 4
Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. The basic defect lies within the IgA immune system and in peripheral blood leukocytes, rather than local kidney abnormalities. To define the intracellular mechanisms leading to the disease, we conducted a microarray study to identify genes and pathways differentially modulated in peripheral blood leukocytes isolated from 12 IgAN patients and 8 healthy controls. The genes whose expression discrimi ...[more]
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