Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Bryan Young
PROVIDER: E-GEOD-14960 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Forshew Tim T Tatevossian Ruth G RG Lawson Andrew R J AR Ma Jing J Neale Geoff G Ogunkolade Babatunji W BW Jones Tania A TA Aarum Johan J Dalton James J Bailey Simon S Chaplin Tracy T Carter Rowena L RL Gajjar Amar A Broniscer Alberto A Young Bryan D BD Ellison David W DW Sheer Denise D
The Journal of pathology 20090601 2
We report genetic aberrations that activate the ERK/MAP kinase pathway in 100% of posterior fossa pilocytic astrocytomas, with a high frequency of gene fusions between KIAA1549 and BRAF among these tumours. These fusions were identified from analysis of focal copy number gains at 7q34, detected using Affymetrix 250K and 6.0 SNP arrays. PCR and sequencing confirmed the presence of five KIAA1549-BRAF fusion variants, along with a single fusion between SRGAP3 and RAF1. The resulting fusion genes la ...[more]