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Comparison of gene expression between follicular thyroid adenoma and follicular thyroid carcinoma

ABSTRACT: Follicular thyroid tumours were investigated using global gene expression analysis. Aim of this study was the identification of new markers for follicular thyroid carcinoma. Keywords: cell type comparison Gene expression analysis of 4 follicular thyroid adenomas, 4 follicular thyroid carcinomas, and 4 microinvasive follicular thyroid carcinomas.

ORGANISM(S): Homo sapiens

SUBMITTER: Nora Hinsch

PROVIDER: E-GEOD-15045 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant; a gene expression, RNA and immunohistochemical study.

Hinsch Nora N Frank Matthias M Döring Claudia C Vorländer Christian C Hansmann Martin-Leo ML

BMC cancer 20090326

<h4>Background</h4>The differential diagnosis between follicular thyroid adenoma and minimal invasive follicular thyroid carcinoma is often difficult for several reasons. One major aspect is the lack of typical cytological criteria in well differentiated specimens. New marker molecules, shown by poly- or monoclonal antibodies proved helpful.<h4>Methods</h4>We performed global gene expression analysis of 12 follicular thyroid tumours (4 follicular adenomas, 4 minimal invasive follicular carcinoma ...[more]

PMID: 19321014

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