Expression profiling of laser-microdissected tissue from Tg2576 plaque-depositing mouse model of Alzheimer's disease
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Wouter Van Delm
PROVIDER: E-GEOD-15056 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.
Pereson Sandra S Wils Hans H Kleinberger Gernot G McGowan Eileen E Vandewoestyne Mado M Van Broeck Bianca B Joris Geert G Cuijt Ivy I Deforce Dieter D Hutton Michael M Van Broeckhoven Christine C Kumar-Singh Samir S
The Journal of pathology 20091001 2
Amyloid-beta (Abeta) plaques are pathological hallmarks of Alzheimer disease (AD). In addition, innate inflammatory responses, such as those mediated by microglia, are integral to the pathogenesis of AD. Interestingly, only dense-core plaques and not diffuse plaques are associated with neuritic and inflammatory pathology in AD patients as well as in mouse AD models. However, the precise neuropathological changes that occur in the brain in response to amyloid deposition are largely unknown. To st ...[more]
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