Gene expression profiles of Themis-deficient thymocytes
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Andy Johnson
PROVIDER: E-GEOD-15246 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Johnson Andy L AL Aravind L L Shulzhenko Natalia N Morgun Andre A Choi See-Young SY Crockford Tanya L TL Lambe Teresa T Domaschenz Heather H Kucharska Edyta M EM Zheng Lixin L Vinuesa Carola G CG Lenardo Michael J MJ Goodnow Christopher C CC Cornall Richard J RJ Schwartz Ronald H RH
Nature immunology 20090713 8
T cell antigen receptor (TCR) signaling in CD4(+)CD8(+) double-positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a previously unknown T lineage-specific gene, Themis, which is critical for the completion of positive selection. Themis contains a tandem repeat of a unique globular domain (called 'CABIT' here) that includes a cysteine moti ...[more]
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