Global transcriptome analysis of Human Bone Marrow Stromal Cells (BMSCs)

ABSTRACT: Abstract Background: Bone marrow stromal cells (BMSCs) are being used for immune modulatory, anti-inflammatory and tissue engineering applications, but the properties responsible for these effects are not completely understood. Human BMSCs were characterized to identify factors that might be responsible for their clinical effects and biomarkers for assessing their quality. Methods: Early passage BMSCs prepared from marrow aspirates of 4 healthy subjects were compared to 3 human embryonic stem cell (hESC) samples, CD34+ cells from 3 healthy subjects and 3 fibroblast cell lines. The cells were analyzed with oligonucleotide expression microarrays with more than 35,000 probes. Results: BMSC gene expression signatures of BMSCs differed from those of hematopoietic stem cells (HSCs), hESCs and fi

ORGANISM(S): Homo sapiens

SUBMITTER: Francesco Marincola 

PROVIDER: E-GEOD-24871 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress