Molecular profiling of breast cancer cell lines defines relevant tumor models
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jonathan Pollack
PROVIDER: E-GEOD-15376 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
Kao Jessica J Salari Keyan K Bocanegra Melanie M Choi Yoon-La YL Girard Luc L Gandhi Jeet J Kwei Kevin A KA Hernandez-Boussard Tina T Wang Pei P Gazdar Adi F AF Minna John D JD Pollack Jonathan R JR
PloS one 20090703 7
<h4>Background</h4>Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it is important to understand how well and which cell lines best model that diversity. In particular, microarray studies have identified molecular subtypes-luminal A, luminal B, ERBB2-associated, basal-like and normal-like-with characteristic gene-expression patterns and underlying DNA copy number alterations (CNA ...[more]
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