Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Kathy Chan
PROVIDER: E-GEOD-15449 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chan Kathy Yuen-Yee KY Xiang Ping P Zhou Ligang L Li Karen K Ng Pak-Cheung PC Wang Chi-Chiu CC Zhang Lei L Deng Hai-Yan HY Pong Nga-Hin NH Zhao Hailu H Chan Wood-Yee WY Sung Rita Yn-Tz RY
European journal of heart failure 20110216 4
<h4>Aims</h4>We investigated the therapeutic efficacy of thrombopoietin (TPO) in acute and chronic rat models of heart damage and explored the mechanisms in terms of genome-wide transcriptional changes, phosphorylation signals, and bone marrow endothelial progenitor cell (EPC) levels.<h4>Methods and results</h4>Cardiac damage was induced in rat models of (i) acute-doxorubicin (DOX) treatment: single high-dose DOX, four doses TPO, followed up for 5 days; and (ii) chronic-DOX treatment: one low-do ...[more]