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Thrombopoietin (TPO) protects against heart damage induced by doxorubicin and infarction in rat models

ABSTRACT: In order to examine the mechanism of TPO on cardiac protection against DOX damage, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to delineate the TPO cardioprotective mechanism against DOX-induced cardiomyopathy Dox and TPO induced gene expressions in rat heart were measured at day 6. Two biological replicates were performed for each treatment group.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Kathy Chan

PROVIDER: E-GEOD-15449 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Thrombopoietin protects against doxorubicin-induced cardiomyopathy, improves cardiac function, and reversely alters specific signalling networks.

Chan Kathy Yuen-Yee KY Xiang Ping P Zhou Ligang L Li Karen K Ng Pak-Cheung PC Wang Chi-Chiu CC Zhang Lei L Deng Hai-Yan HY Pong Nga-Hin NH Zhao Hailu H Chan Wood-Yee WY Sung Rita Yn-Tz RY

European journal of heart failure 20110216 4

<h4>Aims</h4>We investigated the therapeutic efficacy of thrombopoietin (TPO) in acute and chronic rat models of heart damage and explored the mechanisms in terms of genome-wide transcriptional changes, phosphorylation signals, and bone marrow endothelial progenitor cell (EPC) levels.<h4>Methods and results</h4>Cardiac damage was induced in rat models of (i) acute-doxorubicin (DOX) treatment: single high-dose DOX, four doses TPO, followed up for 5 days; and (ii) chronic-DOX treatment: one low-do ...[more]

PMID: 21330293

Publication: 1/2

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