Effect of aging on the meiotic cell cycle
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Monica Boselli
PROVIDER: E-GEOD-15570 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Effects of age on meiosis in budding yeast.
Boselli Monica M Rock Jeremy J Unal Elçin E Levine Stuart S SS Amon Angelika A
Developmental cell 20090601 6
In humans, the frequency with which meiotic chromosome mis-segregation occurs increases with age. Whether age-dependent meiotic defects occur in other organisms is unknown. Here, we examine the effects of replicative aging on meiosis in budding yeast. We find that aged mother cells show a decreased ability to initiate the meiotic program and fail to express the meiotic inducer IME1. The few aged mother cells that do enter meiosis complete this developmental program but exhibit defects in meiotic ...[more]
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