Unknown,Transcriptomics,Genomics,Proteomics

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Effect of aging on the meiotic cell cycle


ABSTRACT: Identify which stages of meiosis are impaired in replicative aging cells Transcriptional profile of aging yeast cells (young and old) incubated in sporulation-inducing conditions compared to new-born cells grown in vegetative conditions. Two conditions experiments. Young and Old cells incubated in sporulation-inducing conditions. Control strain was same strain used for the experimental samples but grown in vegetative conditions.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Monica Boselli 

PROVIDER: E-GEOD-15570 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Effects of age on meiosis in budding yeast.

Boselli Monica M   Rock Jeremy J   Unal Elçin E   Levine Stuart S SS   Amon Angelika A  

Developmental cell 20090601 6


In humans, the frequency with which meiotic chromosome mis-segregation occurs increases with age. Whether age-dependent meiotic defects occur in other organisms is unknown. Here, we examine the effects of replicative aging on meiosis in budding yeast. We find that aged mother cells show a decreased ability to initiate the meiotic program and fail to express the meiotic inducer IME1. The few aged mother cells that do enter meiosis complete this developmental program but exhibit defects in meiotic  ...[more]

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