Transcription profiling of mouse HSC at various time points after treatment with 5-Fluorouracil
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Margaret Goodell
PROVIDER: E-GEOD-1559 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Molecular signatures of proliferation and quiescence in hematopoietic stem cells.
Venezia Teresa A TA Merchant Akil A AA Ramos Carlos A CA Whitehouse Nathan L NL Young Andrew S AS Shaw Chad A CA Goodell Margaret A MA
PLoS biology 20040928 10
Stem cells resident in adult tissues are principally quiescent, yet harbor enormous capacity for proliferation to achieve self renewal and to replenish their tissue constituents. Although a single hematopoietic stem cell (HSC) can generate sufficient primitive progeny to repopulate many recipients, little is known about the molecular mechanisms that maintain their potency or regulate their self renewal. Here we have examined the gene expression changes that occur over a time course when HSCs are ...[more]
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