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Identification of cholangiocarcinoma-like gene expression traits in hepatocellular carcinoma

ABSTRACT: We performed gene expression profiling of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and mixed type of combined HCC and CC (CHC). In comparison of the profiles, a novel class of HCC expressing CC-like traits was identified. Gene expression profiling of 70 hepatocellular carcinoma (HCC), 13 cholangiocarcinoma (CC), and 7 mixed type of combined HCC and CC (CHC) were performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Jeong-Hoon Lee

PROVIDER: E-GEOD-15765 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma.

Woo Hyun Goo HG Park Eun Sung ES Cheon Jae Hee JH Kim Ju Han JH Lee Ju-Seog JS Park Bum Joon BJ Kim Won W Park Su Cheol SC Chung Young Jin YJ Kim Byeong Gwan BG Yoon Jung-Hwan JH Lee Hyo-Suk HS Kim Chung Yong CY Yi Nam-Joon NJ Suh Kyung-Suk KS Lee Kuhn Uk KU Chu In-Sun IS Roskams Tania T Thorgeirsson Snorri S SS Kim Yoon Jun YJ

Clinical cancer research : an official journal of the American Association for Cancer Research 20080401 7

<h4>Purpose</h4>The poor prognosis of hepatocellular carcinoma (HCC) is, in part, due to the high rate of recurrence even after "curative resection" of tumors. Therefore, it is axiomatic that the development of an effective prognostic prediction model for HCC recurrence after surgery would, at minimum, help to identify in advance those who would most benefit from the treatment, and at best, provide new therapeutic strategies for patients with a high risk of early recurrence.<h4>Experimental desi ...[more]

PMID: 18381945

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