Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human Intrahepatic Cholangiocarcinoma (ICC) and Combined Hepatocellular Cholangiocarcinoma (CHC) tumors


ABSTRACT: We compared transcriptomic profiles of 23 ICC tumor specimens to hepatocellular carcinoma (HCC) specimens using Affymetrix mRNA array and the miRNA array platforms to search for unique gene signatures linked to patient prognosis. ICC and HCC share common stem-like molecular characteristics and stem-like tumor features associated with poor prognosis. Gene expression profiling of 16 intrahepatic cholangiocarcinoma (ICC), 7 mixed type of combined HCC and ICC (CHC), 2 Hepatic Adenoma, 5 Focal Nodular Hyperplasia, and 7 Non-Tumor Tissues were performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Wang 

PROVIDER: E-GEOD-32879 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of miR-200c and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma.

Oishi Naoki N   Kumar Mia R MR   Roessler Stephanie S   Ji Junfang J   Forgues Marshonna M   Budhu Anuradha A   Zhao Xuelian X   Andersen Jesper B JB   Ye Qing-Hai QH   Jia Hu-Liang HL   Qin Lun-Xiu LX   Yamashita Taro T   Woo Hyun Goo HG   Kim Yoon Jun YJ   Kaneko Shuichi S   Tang Zhao-You ZY   Thorgeirsson Snorri S SS   Wang Xin Wei XW  

Hepatology (Baltimore, Md.) 20120822 5


<h4>Unlabelled</h4>Intrahepatic cholangiocellular carcinoma (ICC) is the second most common type of primary liver cancer. However, its tumor heterogeneity and molecular characteristics are largely unknown. In this study, we conducted transcriptomic profiling of 23 ICC and combined hepatocellular cholangiocarcinoma tumor specimens from Asian patients using Affymetrix messenger RNA (mRNA) and NanoString microRNA microarrays to search for unique gene signatures linked to tumor subtypes and patient  ...[more]

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