Transcription profiling of rat thrombin-stimulated vascular smooth muscle cells
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ABSTRACT: The strength and duration of extracellular signal-regulated kinases 1/2 (ERK1/2) phosphorylation can define the phenotypic outcome of cells. Stimualtion of the proteinase-activated receptor (Par) triggers a Gi-dependent long-lasting transactivation of the epidermal growth factor receptor and subsequent ERK1/2 phosphorylation. To understand the mechnaisms underlying this signaling cascade, microarray analysis was performed in vascular smooth muscle cells. Experiment Overall Design: Par receptors on neonatal rat aortic smooth muscle cells were stimulated with thrombin or TRAP in presence or abscence of Gi-uncoupling pertussis toxin.
ORGANISM(S): Rattus norvegicus
SUBMITTER: Solveig Grossmann
PROVIDER: E-GEOD-15841 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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