Transcriptomics

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Genome-wide analysis of short-term transcriptional responses in thrombin-stimulated vascular smooth muscle cells


ABSTRACT: The strength and duration of extracellular signal-regulated kinases 1/2 (ERK1/2) phosphorylation can define the phenotypic outcome of cells. Stimualtion of the proteinase-activated receptor (Par) triggers a Gi-dependent long-lasting transactivation of the epidermal growth factor receptor and subsequent ERK1/2 phosphorylation. To understand the mechnaisms underlying this signaling cascade, microarray analysis was performed in vascular smooth muscle cells.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE15841 | GEO | 2009/04/28

SECONDARY ACCESSION(S): PRJNA116815

REPOSITORIES: GEO

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