Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sarah Williams
PROVIDER: E-GEOD-1588 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Williams Sarah S SS Mear John P JP Liang Hung-Chi HC Potter S Steven SS Aronow Bruce J BJ Colbert Melissa C MC
Physiological genomics 20041001 2
Although retinoic acid (RA), the active form of vitamin A, is required for normal embryonic growth and development, it is also a powerful teratogen. Infants born to mothers exposed to retinoids during pregnancy have a 25-fold increased risk for malformations, nearly exclusively of cranial neural crest-derived tissues. To characterize neural crest cell responses to RA, we exposed murine crest cultures to teratogenic levels of RA and subjected their RNA to microarray-based gene expression profile ...[more]