Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael Ochs
PROVIDER: E-GEOD-15966 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rink Lori L Skorobogatko Yuliya Y Kossenkov Andrew V AV Belinsky Martin G MG Pajak Thomas T Heinrich Michael C MC Blanke Charles D CD von Mehren Margaret M Ochs Michael F MF Eisenberg Burton B Godwin Andrew K AK
Molecular cancer therapeutics 20090811 8
Despite initial efficacy of imatinib mesylate in most gastrointestinal stromal tumor (GIST) patients, many experience primary/secondary drug resistance. Therefore, clinical management of GIST may benefit from further molecular characterization of tumors before and after imatinib mesylate treatment. As part of a recent phase II trial of neoadjuvant/adjuvant imatinib mesylate treatment for advanced primary and recurrent operable GISTs (Radiation Therapy Oncology Group S0132), gene expression profi ...[more]