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Transcription profiling of human gastrointestinal stromal tumour is predictive of rapid response to imatinib mesylate


ABSTRACT: Gene expression profiling using oligonucleotide microarrays performed on tumor samples obtained before and after imatinib mesylate (IM) therapy. Rapid responding (to IM) samples were compared to non-responding/stable disease samples as measured by CT scan measurements to identify a gene signature that can predict rapid response to IM. Experiment Overall Design: 54 samples, 29 pre-treatment biopsy samples, 25 post-treatment/post-surgery tumor samples from Gastrointestinal Stromal Tumors

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Ochs 

PROVIDER: E-GEOD-15966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor.

Rink Lori L   Skorobogatko Yuliya Y   Kossenkov Andrew V AV   Belinsky Martin G MG   Pajak Thomas T   Heinrich Michael C MC   Blanke Charles D CD   von Mehren Margaret M   Ochs Michael F MF   Eisenberg Burton B   Godwin Andrew K AK  

Molecular cancer therapeutics 20090811 8


Despite initial efficacy of imatinib mesylate in most gastrointestinal stromal tumor (GIST) patients, many experience primary/secondary drug resistance. Therefore, clinical management of GIST may benefit from further molecular characterization of tumors before and after imatinib mesylate treatment. As part of a recent phase II trial of neoadjuvant/adjuvant imatinib mesylate treatment for advanced primary and recurrent operable GISTs (Radiation Therapy Oncology Group S0132), gene expression profi  ...[more]

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