Sigma factor B (sigB) response to stress conditions (0.05% SDS and 5mM Diamide)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mycobacterium tuberculosis
SUBMITTER: Martin Voskuil
PROVIDER: E-GEOD-15976 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth.
Fontán P A PA Voskuil M I MI Gomez M M Tan D D Pardini M M Manganelli R R Fattorini L L Schoolnik G K GK Smith I I
Journal of bacteriology 20090710 18
The numerous sigma (sigma) factors present in Mycobacterium tuberculosis are indicative of the adaptability of this pathogen to different environmental conditions. In this report, we describe the M. tuberculosis sigma(B) regulon and the phenotypes of an M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia. The sigB mutant was especially defective in survival under hypoxic conditions in vitro, but it was not attenuated for growth in THP-1 cells or duri ...[more]
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