Human Exon Array Profiling of Ewing sarcoma

ABSTRACT: Ewing sarcoma family tumors (ESFTs) are aggressive tumors of putative stem cell origin for which prognostic biomarkers and novel treatments are needed. We have previously shown that the polycomb gene BMI-1 functions as an oncogene in ESFT. In several human cancers, high expression of BMI-1 is associated with poor outcome. For the current study, we evaluated the significance of variable BMI-1 expression levels in a large cohort of primary ESFT. Immunohistochemical staining of 130 tumors revealed that BMI-1 is over-expressed by the vast majority of ESFT. However, in 20% of cases, BMI-1 levels are low to undetectable. Significantly, although clinical presentation and outcome were found to be similar between BMI-1-high and BMI-1-low tumors, gene expression profiling studies showed marked diffe

ORGANISM(S): Homo sapiens

SUBMITTER: Elizabeth Lawlor 

PROVIDER: E-GEOD-16016 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress