Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Meena Upadhyaya
PROVIDER: E-GEOD-16041 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mantripragada Kiran K KK Díaz de Ståhl Teresita T Patridge Chris C Menzel Uwe U Andersson Robin R Chuzhanova Nadia N Kluwe Lan L Guha Abhijit A Mautner Victor V Dumanski Jan P JP Upadhyaya Meena M
Genes, chromosomes & cancer 20091001 10
Neurofibromatosis Type I (NF1) is an autosomal dominant disorder characterized by the development of both benign and malignant tumors. The lifetime risk for developing a malignant peripheral nerve sheath tumor (MPNST) in NF1 patients is approximately 10% with poor survival rates. To date, the molecular basis of MPNST development remains unclear. Here, we report the first genome-wide and high-resolution analysis of DNA copy number alterations in MPNST using the 32K bacterial artificial chromosome ...[more]