Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paul Fawcett
PROVIDER: E-GEOD-16047 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
McCaffrey Anton P AP Fawcett Paul P Nakai Hiroyuki H McCaffrey Ramona L RL Ehrhardt Anja A Pham Thu-Thao T TT Pandey Kusum K Xu Hui H Feuss Sally S Storm Theresa A TA Kay Mark A MA
Molecular therapy : the journal of the American Society of Gene Therapy 20080318 5
Understanding host responses to viral gene therapy vectors is necessary for the development of safe and efficacious in vivo gene transfer agents. We describe the use of high-density spotted complementary DNA microarrays in monitoring the in vivo host transcriptional responses in mouse liver upon administration of either a "first-generation"adenoviral (Ad) vector, a helper-dependent "gutless" adenoviral (HD) vector, or an adeno-associated viral (AAV) vector containing human factor IX (hFIX) expre ...[more]