Unknown,Transcriptomics,Genomics,Proteomics

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Expression in myocardial tissues of Great Dane dogs with cardiomyopathy


ABSTRACT: Oligonucleotide microarray analysis of left ventricular tissues from 3 Great dane dogs with dilated cardiomyopathy and 3 control dogs was performed. Three hundred and twenty three differentially expressed transcripts were detected. The transcript demonstrating the highest degree of upregulation was FKBP12.6 (calstabin2) and the transcript with the greatest amount of down regulation was triadin. Both of these transcripts are critical to proper functioning of the cardiac ryanodine receptor. Abnormalities of both calstabin2 and triadin have been reported in humans with heart disease. Further investigation into the role of calstabin2 and triadin in canine cardiomyopathy is warranted, and the canine disease may serve as a model of human disease. Keywords: control vs diseased 3 controls and 3 affected

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Mark Oyama 

PROVIDER: E-GEOD-16049 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Decreased triadin and increased calstabin2 expression in Great Danes with dilated cardiomyopathy.

Oyama M A MA   Chittur S V SV   Reynolds C A CA  

Journal of veterinary internal medicine 20090805 5


<h4>Background</h4>Dilated cardiomyopathy (DCM) is a common cardiac disease of Great Dane dogs, yet very little is known about the underlying molecular abnormalities that contribute to disease.<h4>Objective</h4>Discover a set of genes that are differentially expressed in Great Dane dogs with DCM as a way to identify candidate genes for further study as well as to better understand the molecular abnormalities that underlie the disease.<h4>Animals</h4>Three Great Dane dogs with end-stage DCM and 3  ...[more]

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