Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Helena Persson
PROVIDER: E-GEOD-16060 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Persson Helena H Kvist Anders A Vallon-Christersson Johan J Medstrand Patrik P Borg Ake A Rovira Carlos C
Nature cell biology 20090913 10
Vault particles are conserved organelles implicated in multidrug resistance and intracellular transport. They contain three different proteins and non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from those in the canonical microRNA (miRNA) pathway. At least one of these svRNAs, svRNAb, associates with Argonaute proteins to guide sequence-specific cleavage and regulate gene expression similarly to miRNAs. We demonstrate that ...[more]