Androgen repsonsive microRNAs in LNCaP cell Lines
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael Haffner
PROVIDER: E-GEOD-16212 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth.
Ribas Judit J Ni Xiaohua X Haffner Michael M Wentzel Erik A EA Salmasi Amirali Hassanzadeh AH Chowdhury Wasim H WH Kudrolli Tarana A TA Yegnasubramanian Srinivasan S Luo Jun J Rodriguez Ron R Mendell Joshua T JT Lupold Shawn E SE
Cancer research 20090908 18
Androgen receptor (AR)-mediated oncogenic pathways have not been fully elucidated. In this study, we used high-throughput microarray analysis on two AR-positive prostate cancer (CaP) cell lines to identify 16 AR-responsive microRNAs (miRNA). We focused on miR-21 because of its previously reported oncogenic activity in other cancers. We show androgen-induced AR binding to the defined miR-21 promoter, miPPR-21, suggesting direct transcriptional regulation. Inhibition of miR-21 diminished androgen- ...[more]
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