Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jordon Wang
PROVIDER: E-GEOD-16221 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Jordon K JK Tsai Miao-Chih MC Poulin Gino G Adler Adam S AS Chen Shuzhen S Liu Helen H Shi Yang Y Chang Howard Y HY
Genes & development 20100201 4
Trimethylation of histone H3 on Lys 27 (H3K27me3) is key for cell fate regulation. The H3K27me3 demethylase UTX functions in development and tumor suppression with undefined mechanisms. Here, genome-wide chromatin occupancy analysis of UTX and associated histone modifications reveals distinct classes of UTX target genes, including genes encoding Retinoblastoma (RB)-binding proteins. UTX removes H3K27me3 and maintains expression of several RB-binding proteins, enabling cell cycle arrest. Genetic ...[more]