HOXA13 Chromatin Immunoprecipitation on human HG18 Nimblegen 2 array promoter set
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Rinn
PROVIDER: E-GEOD-9922 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A dermal HOX transcriptional program regulates site-specific epidermal fate.
Rinn John L JL Wang Jordon K JK Allen Nancy N Brugmann Samantha A SA Mikels Amanda J AJ Liu Helen H Ridky Todd W TW Stadler H Scott HS Nusse Roel R Helms Jill A JA Chang Howard Y HY
Genes & development 20080201 3
Reciprocal epithelial-mesenchymal interactions shape site-specific development of skin. Here we show that site-specific HOX expression in fibroblasts is cell-autonomous and epigenetically maintained. The distal-specific gene HOXA13 is continually required to maintain the distal-specific transcriptional program in adult fibroblasts, including expression of WNT5A, a morphogen required for distal development. The ability of distal fibroblasts to induce epidermal keratin 9, a distal-specific gene, i ...[more]
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