Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

ABSTRACT: RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of human MSI2 in a mouse model increases HSC cell cycle progression and cooperates with the chronic myeloid leukemia-associated BCR-ABL1 oncoprotein to induce an aggressive leukemia. MSI2 is overexpressed in human myeloid leukemia cell lines, and its depletion leads to decreased proliferation and increased apoptosis. Expression levels in human myeloid leukemia directly correlate with decreased survival in patients with the disease, thereby defining MSI2 expression as a new prognostic marker and as a new target for therapy in acute myeloid leukemia (AML). Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc.

ORGANISM(S): Homo sapiens

SUBMITTER: Lars Bullinger

PROVIDER: E-GEOD-16432 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

Kharas Michael G MG Lengner Christopher J CJ Al-Shahrour Fatima F Bullinger Lars L Ball Brian B Zaidi Samir S Morgan Kelly K Tam Winnie W Paktinat Mahnaz M Okabe Rachel R Gozo Maricel M Einhorn William W Lane Steven W SW Scholl Claudia C Fröhling Stefan S Fleming Mark M Ebert Benjamin L BL Gilliland D Gary DG Jaenisch Rudolf R Daley George Q GQ

Nature medicine 20100708 8

RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of human MSI2 in a mouse model increases HSC cell cycle progression and cooperates with the chronic myeloid leukemia-associated BCR-ABL ...[more]

PMID: 20616797

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Dataset Information

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

Publications

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

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