Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Miguel Ramalho-Santos
PROVIDER: E-GEOD-16462 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature 20090708 7257
An open chromatin largely devoid of heterochromatin is a hallmark of stem cells. It remains unknown whether an open chromatin is necessary for the differentiation potential of stem cells, and which molecules are needed to maintain open chromatin. Here we show that the chromatin remodelling factor Chd1 is required to maintain the open chromatin of pluripotent mouse embryonic stem cells. Chd1 is a euchromatin protein that associates with the promoters of active genes, and downregulation of Chd1 le ...[more]