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Gene expression profiling of prostate cells with CHD1 knockdown


ABSTRACT: Gene expression profiling of prostate tumor cells comparing cells that have CHD1 knockdown by shRNA (RWPE-1, OPCN2) or siRNA (LNCaP) with cells treated with non-targeted control. Prostate cell lines had CHD1 knockdown via shRNA or siRNA were hybridized against cells that were targeted with non-targeting control. OPCN2 and RWPE-1 RNA were dye-swapped in replicate experiments.

ORGANISM(S): Homo sapiens

SUBMITTER: Stephanie Huang 

PROVIDER: E-GEOD-33531 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness.

Huang S S   Gulzar Z G ZG   Salari K K   Lapointe J J   Brooks J D JD   Pollack J R JR  

Oncogene 20111219 37


Though prostate cancer is often indolent, it is nonetheless a leading cause of cancer death. Defining the underlying molecular genetic alterations may lead to new strategies for prevention or treatment. Towards this goal, we performed array-based comparative genomic hybridization (CGH) on 86 primary prostate tumors. Among the most frequent alterations not associated with a known cancer gene, we identified focal deletions within 5q21 in 15 out of 86 (17%) cases. By high-resolution tiling array CG  ...[more]

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