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Gene expression profiling of human mammary artery media during aging

ABSTRACT: Our goal was to better understand the genes and pathways implicated during arterial media aging. We therefore compared the gene expression profile of human mammary artery media between Young (<60, 8 patients) and old (>75, 7 patients) patients. The microarray data, generated using the Illumina sentrix Ref8-V2 platform, was normalized and analyzed using the IlluminaGUI package (Eggle and Schultze, 2007). We used 8 samples from the "Young" groups and 7 samples from the "old" group. No technical replicates were used.

ORGANISM(S): Homo sapiens

SUBMITTER: Sophie Nadaud

PROVIDER: E-GEOD-16487 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans.

Marchand Alexandre A Atassi Fabrice F Gaaya Amira A Leprince Pascal P Le Feuvre Claude C Soubrier Florent F Lompré Anne-Marie AM Nadaud Sophie S

Aging cell 20101229 2

Aging is the main risk factor for cardiovascular diseases, but the associated molecular mechanisms are poorly understood. The Wnt signaling pathway was shown to be induced during aging in muscle and in the skin, but the regulation and role of Wnt signaling in the aged vessel have not yet been addressed. While screening for age-related changes in gene expression in the intima/media of human mammary arteries, we observed that the expression of frizzled 4 (Fzd4), a Wnt receptor, and of several targ ...[more]

PMID: 21108734

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