Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Differential gene expression between ERRa KO and WT mouse kidneys

ABSTRACT: Estrogen-related receptor (ERR) alpha is an orphan nuclear receptor highly expressed in the kidneys. ERRalpha is implicated in renal sodium and potassium homeostasis and blood pressure regulation. We used microarray analysis to identify differentially expressed genes in ERR alpha knockout mice kidneys versus wild-type. The results provide insight on the roles of ERRalpha in the kidney. Three biological replicates of WT and ERRaKO were performed, for a total of 6 samples. 2-3 month old males of each genotype were used.

ORGANISM(S): Mus musculus

SUBMITTER: Vincent Giguere

PROVIDER: E-GEOD-16623 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway.

Tremblay Annie M AM Dufour Catherine R CR Ghahremani Majid M Reudelhuber Timothy L TL Giguère Vincent V

Molecular endocrinology (Baltimore, Md.) 20091109 1

Estrogen-related receptor alpha (ERRalpha) is an orphan nuclear receptor highly expressed in the kidney, an organ playing a central role in blood pressure regulation through electrolyte homeostasis and the renin-angiotensin system. Physiological analysis revealed that, relative to wild-type mice, ERRalpha null mice are hypotensive despite significant hypernatremia, hypokalemia, and slight hyperreninemia. Using a combination of genome-wide location analysis and expression profiling, we demonstrat ...[more]

PMID: 19901197

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Dataset Information

Differential gene expression between ERRa KO and WT mouse kidneys

Publications

Physiological genomics identifies estrogen-related receptor alpha as a regulator of renal sodium and potassium homeostasis and the renin-angiotensin pathway.

Similar Datasets

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