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Differential gene expression in CD11b+ splenocytes from mice subject to social threat vs. control

ABSTRACT: Gene expression profiling was carried out on splenocyte mRNA samples collected from 10 animals subject to repeated social threat (pooled into 2 groups of 5) and 10 animals subject to non-threatening control conditions (pooled into 2 groups of 5). The primary research question is whether gene expression differs in CD11b+ splenocytes from animals exposed to social threat vs non-threatening control conditions. Keywords: Risk prediction RNA from 5 mice/sample was pooled to generate 4 total samples: 2 from mice subject to repeated social threat, and 2 from control mice.

ORGANISM(S): Mus musculus

SUBMITTER: Steve Cole

PROVIDER: E-GEOD-16661 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Computational identification of gene-social environment interaction at the human IL6 locus.

Cole Steven W SW Arevalo Jesusa M G JM Takahashi Rie R Sloan Erica K EK Lutgendorf Susan K SK Sood Anil K AK Sheridan John F JF Seeman Teresa E TE

Proceedings of the National Academy of Sciences of the United States of America 20100222 12

To identify genetic factors that interact with social environments to impact human health, we used a bioinformatic strategy that couples expression array-based detection of environmentally responsive transcription factors with in silico discovery of regulatory polymorphisms to predict genetic loci that modulate transcriptional responses to stressful environments. Tests of one predicted interaction locus in the human IL6 promoter (SNP rs1800795) verified that it modulates transcriptional response ...[more]

PMID: 20176930

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